Article
Genetic polymorphisms of NOD1 and IL-8, but not polymorphisms of TLR4 genes, are associated with Helicobacter pylori-induced duodenal ulcer and gastritis.
Helicobacter - 1 Apr 2007
Hofner Peter, Gyulai Zsofia, Kiss Zsuzsanna F, Tiszai Andrea, Tiszlavicz László, Tóth Gábor, Szõke Dominika, Molnár Béla, Lonovics János, Tulassay Zsolt, Mándi Yvette
Abstract excerpt
BACKGROUND: Intracellular pathogen receptor NOD1 is involved in the epithelial cell sensing Helicobacter pylori, which results in a considerable interleukin (IL)-8 production. The aim of this study was to evaluate the relationship between NOD1 and IL-8 genetic polymorphisms and the development of H. pylori-induced gastritis and duodenal ulcer (DU), as compared with TLR4 polymorphisms. MATERIALS AND METHODS:...
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