Article
Enterococcus faecalis mutations affecting virulence in the Caenorhabditis elegans model host.
Infection and immunity - 1 May 2007
Maadani Arash, Fox Kristina A, Mylonakis Elftherios, Garsin Danielle A
Abstract excerpt
Enterococcus faecalis transposon insertion mutants were screened for attenuated killing of the nematode model host Caenorhabditis elegans. The genes disrupted in the attenuated mutants encode a variety of factors including transcriptional regulators, transporters, and damage control and repair systems. Five of nine mutants tested were attenuated in a mouse peritonitis model.
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