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Article

Repeat length polymorphism of the serotonin transporter gene influences pulmonary artery pressure in heart failure.

American heart journal - 1 Mar 2007

Olson Thomas P, Snyder Eric M, Frantz Robert P, Turner Stephen T, Johnson Bruce D

Abstract excerpt

BACKGROUND: Pulmonary hypertension is common in patients with heart failure (HF); however, for a given degree of left ventricular dysfunction, the range in pulmonary artery pressures (PAPs) is large. Polymorphisms of the serotonin transporter (5-HTT) gene have been implicated in contributing to smooth muscle dysfunction and remodeling of the pulmonary vasculature. This study examined the influence of a repeat...

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Share to Echocardiography, Doppler
Share to Heart Failure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension, Pulmonary

Share to Promoter Regions, Genetic

Share to Serotonin Plasma Membrane Transport Proteins

Share to Stroke Volume

Share to Up-Regulation

Share to Ventricular Dysfunction, Left

Source

Identifiers

PMID: 17307423
DOI: 10.1016/j.ahj.2006.12.011

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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