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Article

Association study of serotonin transporter gene (SLC6A4) in systemic sclerosis in European Caucasian populations.

The Journal of rheumatology - 1 Jun 2010

Wipff Julien, Bonnet Pierre, Ruiz Barbara, Dieude Philippe, Avouac Jerome, Tiev Kiet, Hachulla Eric, Cracowski Jean-Luc, Diot Elizabeth, Sibilia Jean, Mouthon Luc, Meyer Olivier, Kahan Andre, Boileau Catherine, Allanore Yannick

Abstract excerpt

OBJECTIVE: Serotonin is a key contributing factor in pulmonary arterial hypertension (PAH) by inducing pulmonary arterial smooth muscle cell (PA-SMC) proliferation. This relates specifically to the internalization process in PA-SMC of the serotonin transporter (SLC6A4 or 5-HTT). A long (L)/short (S) (44 base pair insertion) functional polymorphism within the promoter of the transporter SLC6A4 gene has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20395645
DOI: 10.3899/jrheum.091156

Genes

PAH
HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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