Article
Serotonin transporter polymorphisms in familial and idiopathic pulmonary arterial hypertension.
American journal of respiratory and critical care medicine - 1 Apr 2006
Willers Elisabeth D, Newman John H, Loyd James E, Robbins Ivan M, Wheeler Lisa A, Prince Melissa A, Stanton Krista C, Cogan Joy A, Runo James R, Byrne Daniel, Humbert Marc, Simonneau Gerald, Sztrymf Benjamin, Morse Jane A, Knowles James A, Roberts Kari E, McElroy Jude J, Barst Robyn J, Phillips John A
Abstract excerpt
RATIONALE: Serotonin is a pulmonary vasoconstrictor and smooth muscle cell mitogen. The serotonin transporter (SERT) is abundant in pulmonary vascular smooth muscle. Compared with the short (S) allele, the long (L) SERT promoter allele is associated with increased SERT transcription and more severe pulmonary hypertension in a cohort of patients with chronic obstructive pulmonary disease, and was more prevalent in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.