Article
Identification of universal selectivity-determining positions in cytochrome P450 monooxygenases by systematic sequence-based literature mining.
Proteins - 1 Sept 2015
Gricman Łukasz, Vogel Constantin, Pleiss Jürgen
Abstract excerpt
Cytochrome P450 monooxygenases (CYPs) are a large, highly diverse protein family with a common fold. The sequences, structures, and functions of CYPs have been extensively studied resulting in more than 53,000 scientific articles. A sequence-based literature mining algorithm was designed to systematically analyze this wealth of information on SNPs, designed mutations, structural interactions, or functional roles...
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