Article
Analysis of ITPA phenotype-genotype correlation in the Bulgarian population revealed a novel gene variant in exon 6.
Therapeutic drug monitoring - 1 Feb 2007
Atanasova Srebrena, Shipkova Maria, Svinarov Dobrin, Mladenova Antoaneta, Genova Mariana, Wieland Eberhard, Oellerich Michael, von Ahsen Nicolas
Abstract excerpt
Mutations in the inosine triphosphate pyrophosphohydrolase (ITPA) gene causing enzyme deficiency were shown to have pharmacogenetic implications in azathioprine-induced adverse drug reactions. The distribution of ITPA activity as well as the types and the frequencies of gene variants associated with a lower enzyme activity were determined in healthy volunteers from a Bulgarian population. The ITPA activity was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.