Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Measurement of erythrocyte inosine triphosphate pyrophosphohydrolase (ITPA) activity by HPLC and correlation of ITPA genotype-phenotype in a Caucasian population.

Clinical chemistry - 1 Feb 2006

Shipkova Maria, Lorenz Kristin, Oellerich Michael, Wieland Eberhard, von Ahsen Nicolas

Abstract excerpt

BACKGROUND: Inosine triphosphate (ITP) pyrophosphohydrolase (ITPA) catalyzes the pyrophosphohydrolysis of ITP/dITP and xanthosine triphosphate to prevent incorporation of unusual nucleotides into RNA and DNA. Important mutations leading to enzyme deficiency are 94C>A and IVS2 + 21A>C. An association between ITPA 94C>A and adverse reactions during azathioprine treatment has been shown. To investigate the ITPA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatography, High Pressure Liquid
Share to Erythrocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genotype

Share to Phenotype

Share to Pyrophosphatases

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to White People

Source

Identifiers

PMID: 16384889
DOI: 10.1373/clinchem.2005.059501

Genes

ITPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Measurement of erythrocyte inosine triphosphate pyrophosphohydrolase (ITPA) activity by HPLC and correlation of ITPA genotype-phenotype in a Caucasian population.PMID 16384889Read ↗

Determination of inosine triphosphate pyrophosphatase phenotype in human red blood cells using HPLC.Semantic proximity Read ↗

Analysis of ITPA phenotype-genotype correlation in the Bulgarian population revealed a novel gene variant in exon 6.Semantic proximity Read ↗

The ITPA c.94C>A and g.IVS2+21A>C sequence variants contribute to missplicing of the ITPA gene.Semantic proximity Read ↗

Characterization of the inosine triphosphatase (ITPA) gene: haplotype structure, haplotype-phenotype correlation and promoter function.Semantic proximity Read ↗

Pharmacogenetic significance of inosine triphosphatase.Semantic proximity Read ↗

Allele frequency of inosine triphosphate pyrophosphatase gene polymorphisms in a Japanese population.Semantic proximity Read ↗

Erythrocyte inosine triphosphatase activity is decreased in HIV-seropositive individuals.Semantic proximity Read ↗

Inosine Triphosphate Pyrophosphatase (ITPase): Functions, Mutations, Polymorphisms and Its Impact on Cancer Therapies.Semantic proximity Read ↗

A disease spectrum for ITPA variation: advances in biochemical and clinical research.Semantic proximity Read ↗

Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency in the Japanese population.Semantic proximity Read ↗

Pharmacogenetics of the mycophenolic acid targets inosine monophosphate dehydrogenases IMPDH1 and IMPDH2: gene sequence variation and functional genomics.Semantic proximity Read ↗

ITPA gene polymorphisms significantly affect hemoglobin decline and treatment outcomes in patients coinfected with HIV and HCV.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.