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Article

Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain.

Brain : a journal of neurology - 1 Mar 2007

Eslamboli Andisheh, Romero-Ramos Marina, Burger Corinna, Bjorklund Tomas, Muzyczka Nicholas, Mandel Ronald J, Baker Harry, Ridley Rosalind M, Kirik Deniz

Abstract excerpt

Overexpression of human alpha-synuclein (alpha-syn) using recombinant adeno-associated viral (rAAV) vectors provides a novel tool to study neurodegenerative processes seen in Parkinson's disease and other synucleinopathies. We used a pseudotyped rAAV2/5 vector to express human wild-type (wt) alpha-syn, A53T mutated alpha-syn, or the green fluorescent protein (GFP) in the primate ventral midbrain. Twenty-four...

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PMID: 17303591
DOI: 10.1093/brain/awl382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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