Changes in 2-hydroxyestrone and 16alpha-hydroxyestrone metabolism with flaxseed consumption: modification by COMT and CYP1B1 genotype.

doi:10.1158/1055-9965.EPI-06-0633

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Article

Changes in 2-hydroxyestrone and 16alpha-hydroxyestrone metabolism with flaxseed consumption: modification by COMT and CYP1B1 genotype.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2007

McCann Susan E, Wactawski-Wende Jean, Kufel Kari, Olson James, Ovando Bladimir, Kadlubar Susan Nowell, Davis Warren, Carter Lisa, Muti Paola, Shields Peter G, Freudenheim Jo L

Abstract excerpt

Consumption of the phytoestrogen lignans, structurally similar to estrogen, has been associated with alterations in gene expression and estrogen metabolism. Furthermore, lignan consumption, subsequent changes in metabolizing enzyme expression, and genetic variability in these enzymes may alter estrogen metabolism and modify disease risk. Therefore, we investigated the effect of flaxseed on hydroxyestrone...

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Identifiers

PMID: 17301257
DOI: 10.1158/1055-9965.EPI-06-0633
PMCID: PMC5613245

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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