Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two mutations convert mammalian xanthine oxidoreductase to highly superoxide-productive xanthine oxidase.

Journal of biochemistry - 1 Apr 2007

Asai Ryosuke, Nishino Tomoko, Matsumura Tomohiro, Okamoto Ken, Igarashi Kiyohiko, Pai Emil F, Nishino Takeshi

Abstract excerpt

Reactive oxygen species are generated by various systems, including NADPH oxidases, xanthine oxidoreductase (XOR) and mitochondrial respiratory enzymes, and contribute to many physiological and pathological phenomena. Mammalian xanthine dehydrogenase (XDH) can be converted to xanthine oxidase (XO), which produces both superoxide anion and hydrogen peroxide in a molar ratio of about 1:3, depending upon the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crystallography, X-Ray
Share to Dithiothreitol

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Flavin-Adenine Dinucleotide

Share to Reactive Oxygen Species

Share to Spodoptera

Share to Superoxides

Share to Xanthine Dehydrogenase

Share to Xanthine Oxidase

Source

Identifiers

PMID: 17301076
DOI: 10.1093/jb/mvm054

Genes

XDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two mutations convert mammalian xanthine oxidoreductase to highly superoxide-productive xanthine oxidase.PMID 17301076Read ↗

Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate.Semantic proximity Read ↗

Mutations associated with functional disorder of xanthine oxidoreductase and hereditary xanthinuria in humans.Semantic proximity Read ↗

Mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase: identification of the two cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine dehydrogenase mutant.Semantic proximity Read ↗

Association of Mutations Identified in Xanthinuria with the Function and Inhibition Mechanism of Xanthine OxidoreductaseSemantic proximity Read ↗

Natural mutations of human XDH promote the nitrite (NO2-)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?Semantic proximity Read ↗

Mechanism of transition from xanthine dehydrogenase to xanthine oxidase: effect of guanidine-HCL or urea on the activity.Semantic proximity Read ↗

Natural mutations of human <i>XDH</i> promote the nitrite (NO <sub>2</sub> <sup>-</sup> )-reductase capacity of xanthine oxidoreductase: a novel mechanism to promote redox health?Semantic proximity Read ↗

Recombinant Rhodobacter capsulatus Xanthine Dehydrogenase, a Useful Model System for the Characterization of Protein Variants Leading to Xanthinuria I in HumansSemantic proximity Read ↗

Modifying the resolving cysteine affects the structure and hydrogen peroxide reactivity of peroxiredoxin 2.Semantic proximity Read ↗

Engineering the respiratory complex I to energy-converting NADPH:ubiquinone oxidoreductase.Semantic proximity Read ↗

Two enzymes in one; two yeast peroxiredoxins display oxidative stress-dependent switching from a peroxidase to a molecular chaperone function.Semantic proximity Read ↗

A single nucleotide polymorphism causes enhanced radical oxygen species production by human aldehyde oxidase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.