Article
Engineering the respiratory complex I to energy-converting NADPH:ubiquinone oxidoreductase.
The Journal of biological chemistry - 7 Oct 2011
Morina Klaudia, Schulte Marius, Hubrich Florian, Dörner Katerina, Steimle Stefan, Stolpe Stefan, Friedrich Thorsten
Abstract excerpt
The respiratory complex I couples the electron transfer from NADH to ubiquinone with a translocation of protons across the membrane. Its nucleotide-binding site is made up of a unique Rossmann fold to accommodate the binding of the substrate NADH and of the primary electron acceptor flavin mononucleotide. Binding of NADH includes interactions of the hydroxyl groups of the adenosine ribose with a conserved...
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