Article
Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk.
Carcinogenesis - 1 Jul 2007
Frank Bernd, Bermejo Justo Lorenzo, Hemminki Kari, Sutter Christian, Wappenschmidt Barbara, Meindl Alfons, Kiechle-Bahat Marion, Bugert Peter, Schmutzler Rita K, Bartram Claus R, Burwinkel Barbara
Abstract excerpt
Copy number variants (CNVs), insertions, deletions and duplications, contribute considerably to human genetic variation and disease development. A recent study has characterized 100 CNVs including a deletion in the mitochondrial tumor suppressor gene 1 (MTUS1) lacking the coding exon 4. MTUS1 maps to chromosome 8p, a region frequently deleted and associated with disease progression in human cancers, including...
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