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Article

Breast cancer associated germline structural variants harboring small noncoding RNAs impact post-transcriptional gene regulation.

Scientific reports - 14 May 2018

Kumaran Mahalakshmi, Krishnan Preethi, Cass Carol E, Hubaux Roland, Lam Wan, Yasui Yutaka, Damaraju Sambasivarao

Abstract excerpt

Copy Number Variants (CNVs) are a class of structural variations of DNA. Germline CNVs are known to confer disease susceptibility, but their role in breast cancer warrants further investigations. We hypothesized that breast cancer associated germline CNVs contribute to disease risk through gene dosage or other post-transcriptional regulatory mechanisms, possibly through tissue specific expression of CNV-embedded...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29760470
DOI: 10.1038/s41598-018-25801-1
PMCID: PMC5951800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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