Article
NRF-2 transcription factor is required for human TOMM20 gene expression.
Gene - 15 Apr 2007
Blesa José R, Prieto-Ruiz Jesús A, Hernández José M, Hernández-Yago José
Abstract excerpt
TOMM20 is a subunit of the outer mitochondrial membrane translocase that plays a major role as a receptor of precursor proteins with N-terminal cleavable presequences targeted to the mitochondria. Nuclear respiratory factors 1 and 2 (NRF-1 and NRF-2) play an important role in governing nucleo-mitochondrial interactions implicated in mitochondrial biogenesis. It was recently reported that NRF-2 is critical for...
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