Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

27 Jun 2000

Abstract excerpt

Huntington's disease (HD) is a fatal inherited neurodegenerative disorder characterized by personality changes, motor impairment, and subcortical dementia. HD is one of a number of diseases caused by expression of an expanded polyglutamine repeat. We have developed several lines of mice that are transgenic for exon 1 of the HD gene containing an expanded CAG sequence. These mice exhibit a defined neurological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Neurodegenerative Diseases
Share to Mitochondrial Function and Pathology
Share to Neurological disorders and treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10869421
DOI: 10.1073/pnas.110078997

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's diseasePMID 10869421Read ↗

From neuronal inclusions to neurodegeneration: neuropathological investigation of a transgenic mouse model of Huntington'sdiseaseSemantic proximity Read ↗

The molecular biology of Huntington's disease.Semantic proximity Read ↗

Cellular and subcellular localization of Huntington aggregates in the brain of a rat transgenic for Huntington diseaseSemantic proximity Read ↗

Neocortical expression of mutant huntingtin is not required for alterations in striatal gene expression or motor dysfunction in a transgenic mouse.Semantic proximity Read ↗

The use of transgenic and knock-in mice to study Huntington's disease.Semantic proximity Read ↗

Transgenic animal models for study of the pathogenesis of Huntington's disease and therapy.Semantic proximity Read ↗

Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.Semantic proximity Read ↗

Selective degeneration in YAC mouse models of Huntington disease.Semantic proximity Read ↗

Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease.Semantic proximity Read ↗

Mouse Models of Huntington's Disease.Semantic proximity Read ↗

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.Semantic proximity Read ↗

Mutant huntingtin can paradoxically protect neurons from death.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.