Article
Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle.
Proceedings of the National Academy of Sciences of the United States of America - 2 Mar 2010
Guerrero Astrid Alonso, Gamero Mercedes Cano, Trachana Varvara, Fütterer Agnes, Pacios-Bras Cristina, Díaz-Concha Nuria Panadero, Cigudosa Juan Cruz, Martínez-A Carlos, van Wely Karel H M
Abstract excerpt
Most carcinomas present some form of chromosome instability in combination with spindle defects. Numerical instability is likely caused by spindle aberrations, but the origin of breaks and translocations remains elusive. To determine whether one mechanism can bring about both types of instability, we studied the relationship between DNA damage and spindle defects. Although lacking apparent repair defects, primary...
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