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Article

Degenerate in vitro genetic selection reveals mutations that diminish alfalfa mosaic virus RNA replication without affecting coat protein binding.

Journal of virology - 1 Aug 2004

Rocheleau Gail, Petrillo Jessica, Guogas Laura, Gehrke Lee

Abstract excerpt

The alfalfa mosaic virus (AMV) RNAs are infectious only in the presence of the viral coat protein; however, the mechanisms describing coat protein's role during replication are disputed. We reasoned that mechanistic details might be revealed by identifying RNA mutations in the 3'-terminal coat protein binding domain that increased or decreased RNA replication without affecting coat protein binding. Degenerate...

Topics

3' Untranslated Regions
Alfalfa mosaic virus
Amino Acid Sequence
Base Sequence
Capsid Proteins
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Protein Binding
Protein Biosynthesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Viral

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Identifiers

PMID: 15254175
DOI: 10.1128/JVI.78.15.8036-8046.2004
PMCID: PMC446135

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