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Article

PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion.

Oncogene - 26 Jul 2007

Liu X, Hu Y, Hao C, Rempel S A, Ye K

Abstract excerpt

PIKE-A (phosphoinositide 3-kinases (PI 3)-kinase enhancer) is a ubiquitously expressed GTPase, which binds to and enhances protein kinase B (Akt) kinase activity in a guanine nucleotide-dependent manner. PIKE-A is one of the components of the CDK4 amplicon that is amplified in numerous human cancers. However, whether PIKE-A itself can mediate cell transformation, proliferation and migration remains unknown. Here,...

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Source

Identifiers

PMID: 17297440
DOI: 10.1038/sj.onc.1210290

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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