Article
Suppression of keratinocyte stratification by a dominant negative JunB mutant without blocking cell proliferation.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Feb 2007
Ikebe Dai, Wang Bei, Suzuki Hiroyuki, Kato Mitsuyasu
Abstract excerpt
Keratinocytes make a stratified epidermoid structure when cultured at an air-liquid interface. The three-dimensional (3D) culture of keratinocytes has been successfully used for more than 25 years, but it is still unclear why keratinocytes stratify in response to air exposure. AP-1 proteins are ubiquitous transcription factors that regulate many biological processes, including cell proliferation, differentiation...
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