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Article

Construction and validation of a RET TK catalytic domain by homology modeling.

Journal of chemical information and modeling - 1 Jan 2000

Tuccinardi Tiziano, Manetti Fabrizio, Schenone Silvia, Martinelli Adriano, Botta Maurizio

Abstract excerpt

RET tyrosine kinase (TK) oncoproteins are potential targets for anticancer therapy. However, the search for novel RET inhibitors has been hampered by the lack of a 3D structure of the receptor. In this study, the "open" and the "closed" structure of the RET TK catalytic domain have been built by...

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Share to Catalytic Domain
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17295463
DOI: 10.1021/ci6004383

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17295463-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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