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Article

RET kinase inhibitors: a review of recent patents (2012–2015)

20 Sept 2016

Abstract excerpt

INTRODUCTION: Tyrosine kinases are involved in the control of several biological processes and have been recognized as hot spots of oncogenic transformation, thus representing a major therapeutic target. Dysregulated activation of RET kinase, either through point mutations or gene fusions, is accountable for a significant fraction of thyroid carcinomas, as well as a minor population of lung cancers. Two drugs are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27646564
DOI: 10.1080/13543776.2017.1238073

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