Article
High-throughput oncogene mutation profiling in human cancer.
Nature genetics - 1 Mar 2007
Thomas Roman K, Baker Alissa C, Debiasi Ralph M, Winckler Wendy, Laframboise Thomas, Lin William M, Wang Meng, Feng Whei, Zander Thomas, MacConaill Laura, Macconnaill Laura E, Lee Jeffrey C, Nicoletti Rick, Hatton Charlie, Goyette Mary, Girard Luc, Majmudar Kuntal, Ziaugra Liuda, Wong Kwok-Kin, Gabriel Stacey, Beroukhim Rameen, Peyton Michael, Barretina Jordi, Dutt Amit, Emery Caroline, Greulich Heidi, Shah Kinjal, Sasaki Hidefumi, Gazdar Adi, Minna John, Armstrong Scott A, Mellinghoff Ingo K, Hodi F Stephen, Dranoff Glenn, Mischel Paul S, Cloughesy Tim F, Nelson Stan F, Liau Linda M, Mertz Kirsten, Rubin Mark A, Moch Holger, Loda Massimo, Catalona William, Fletcher Jonathan, Signoretti Sabina, Kaye Frederic, Anderson Kenneth C, Demetri George D, Dummer Reinhard, Wagner Stephan, Herlyn Meenhard, Sellers William R, Meyerson Matthew, Garraway Levi A
Abstract excerpt
Systematic efforts are underway to decipher the genetic changes associated with tumor initiation and progression. However, widespread clinical application of this information is hampered by an inability to identify critical genetic events across the spectrum of human tumors with adequate sensitivity and scalability. Here, we have adapted high-throughput genotyping to query 238 known oncogene mutations across...
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