Article
The influence of the AA 16 beta 2-adrenoceptor polymorphism on systemic and airway responses in asthma.
Pulmonary pharmacology & therapeutics - 1 Jan 2008
van Veen Anneke, Weller Frank R, Wierenga Eddy A, Jansen Henk M, Jonkers René E
Abstract excerpt
BACKGROUND: The impact of the polymorphic amino acids 16 and 27 of the beta 2-adrenoceptor (beta 2-AR) on the susceptibility to bronchodilator tolerance remains unclear since clinical studies thus far have shown discordant results. Tolerance towards the effects of inhaled beta 2-AR agonists generally is more easily shown for systemic parameters than for airway effects and can be substantial. This study evaluates...
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