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Article

Differential biological role of CD3 chains revealed by human immunodeficiencies.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2007

Recio María J, Moreno-Pelayo Miguel Angel, Kiliç Sara S, Guardo Alberto C, Sanal Ozden, Allende Luis M, Pérez-Flores Verónica, Mencía Angeles, Modamio-Høybjør Silvia, Seoane Elena, Regueiro José R

Abstract excerpt

The biological role in vivo of the homologous CD3gamma and delta invariant chains within the human TCR/CD3 complex is a matter of debate, as murine models do not recapitulate human immunodeficiencies. We have characterized, in a Turkish family, two new patients with complete CD3gamma deficiency and SCID symptoms and compared them with three CD3gamma-deficient individuals belonging to two families from Turkey and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell, alpha-beta

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Identifiers

PMID: 17277165
DOI: 10.4049/jimmunol.178.4.2556

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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