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Article

Effect of gender on phenotypic expression of the S447X mutation in LPL: the Copenhagen City Heart Study.

Atherosclerosis - 1 Nov 2002

Wittrup Hans H, Nordestgaard Børge G, Steffensen Rolf, Jensen Gorm, Tybjaerg-Hansen Anne

Abstract excerpt

The G188E, D9N, and N291S mutations in LPL increase TG, reduce HDL cholesterol, and increase risk of ischemic heart disease. The common S447X mutation may have opposite effects. We genotyped 8451 women and men from the Danish general population, and 854 women and men with ischemic heart disease....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12208477
DOI: 10.1016/s0021-9150(02)00183-1

Genes

LPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12208477-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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Effect of gender on phenotypic expression of the S447X mutation in LPL: the Copenhagen City Heart Study.PMID 12208477Read ↗

Common cholesteryl ester transfer protein mutations, decreased HDL cholesterol, and possible decreased risk of ischemic heart disease: The Copenhagen City Heart Study.Semantic proximity Read ↗

The lipoprotein lipase gene serine 447 stop variant influences hypertension-induced left ventricular hypertrophy and risk of coronary heart disease.Semantic proximity Read ↗

Lipoprotein lipase mutations, plasma lipids and lipoproteins, and risk of ischemic heart disease. A meta-analysis.Semantic proximity Read ↗

A common substitution (Asn291Ser) in lipoprotein lipase is associated with increased risk of ischemic heart disease.Semantic proximity Read ↗

S447X variant of the lipoprotein lipase gene, lipids, and risk of coronary heart disease in 3 prospective cohort studies.Semantic proximity Read ↗

A common truncation variant of lipoprotein lipase (Ser447X) confers protection against coronary heart disease: the Framingham Offspring Study.Semantic proximity Read ↗

[Frequent mutation doubles the risk of ischemic heart disease in women].Semantic proximity Read ↗

Lipoprotein lipase D9N, N291S and S447X polymorphisms: their influence on premature coronary heart disease and plasma lipids.Semantic proximity Read ↗

The association of the S447X mutation in LPL with Coronary artery disease: a meta-analysis.Semantic proximity Read ↗

Combined analysis of six lipoprotein lipase genetic variants on triglycerides, high-density lipoprotein, and ischemic heart disease: cross-sectional, prospective, and case-control studies from the Copenhagen City Heart Study.Semantic proximity Read ↗

Lipoprotein lipase variants D9N and N291S are associated with increased plasma triglyceride and lower high-density lipoprotein cholesterol concentrations: studies in the fasting and postprandial states: the European Atherosclerosis Research Studies.Semantic proximity Read ↗

The S447X variant of lipoprotein lipase gene is associated with metabolic syndrome and lipid levels among Turks.Semantic proximity Read ↗

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