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Dynamics of DNA‐demethylation in early mouse and rat embryos developed in vivo and in vitro

8 Feb 2007

Abstract excerpt

Virtually all mammalian species including mouse, rat, pig, cow, and human, but not sheep and rabbit, undergo genome-wide epigenetic reprogramming by demethylation of the male pronucleus in early preimplantation development. In this study, we have investigated and compared the dynamics of DNA demethylation in preimplantation mouse and rat embryos by immunofluorescence staining with an antibody against...

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PMID: 17290422
DOI: 10.1002/mrd.20704

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