Article
Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy.
Molecular cell - 9 Feb 2007
Ottmann Christian, Marco Sergio, Jaspert Nina, Marcon Caroline, Schauer Nicolas, Weyand Michael, Vandermeeren Caroline, Duby Geoffrey, Boutry Marc, Wittinghofer Alfred, Rigaud Jean-Louis, Oecking Claudia
Abstract excerpt
Regulatory 14-3-3 proteins activate the plant plasma membrane H(+)-ATPase by binding to its C-terminal autoinhibitory domain. This interaction requires phosphorylation of a C-terminal, mode III, recognition motif as well as an adjacent span of approximately 50 amino acids. Here we report the X-ray crystal structure of 14-3-3 in complex with the entire binding motif, revealing a previously unidentified mode of...
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