Use of the polymerase chain reaction mismatch technique to identify the HLA-DQw8 allele in patients with insulin-dependent diabetes mellitus.

doi:10.1093/ajcp/97.1.29

Back to search

Article

Use of the polymerase chain reaction mismatch technique to identify the HLA-DQw8 allele in patients with insulin-dependent diabetes mellitus.

American journal of clinical pathology - 1 Jan 1992

Mahran M Z, Ross D G, Sadeghi-Nejad A, Rabson A R

Abstract excerpt

The allelic forms of the HLA-DQB gene have been recognized as susceptibility markers of type 1 diabetes mellitus. One of these alleles, the DQw3.2 (DQw8), accounts for the well-documented association of the DQw3 locus with the disease. This report describes a method using the polymerase chain rea...

Topics

Alleles
Base Sequence
DNA
Diabetes Mellitus, Type 1
Genes, MHC Class II
HLA-DQ Antigens
Humans
Molecular Sequence Data
Oligonucleotides
Polymerase Chain Reaction

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.