Article
Constitutive myc expression impairs hypertrophy and calcification in cartilage.
Developmental biology - 1 Jan 1992
Quarto R, Dozin B, Tacchetti C, Robino G, Zenke M, Campanile G, Cancedda R
Abstract excerpt
The myc oncogene is expressed by proliferating quail embryo chondrocytes (QEC) grown as adherent cells and is repressed in QEC maintained in suspension culture. To investigate the interference of myc expression during chondrocyte differentiation, QEC were infected with a retrovirus carrying the v-myc oncogene (QEC-v-myc). Uninfected or helper virus-infected QEC were used as control. In adherent culture, QEC-v-myc...
Topics
- Animals
- Calcification, Physiologic
- Cartilage
- Cell Division
- Cells, Cultured
- Chick Embryo
- Collagen
- Fluorescent Antibody Technique
- Gene Expression
- Genes, myc
- Hypertrophy