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Article

The nonmuscle myosin phosphatase PP1beta (flapwing) negatively regulates Jun N-terminal kinase in wing imaginal discs of Drosophila.

Genetics - 1 Apr 2007

Kirchner Jasmin, Gross Sascha, Bennett Daimark, Alphey Luke

Abstract excerpt

Drosophila flapwing (flw) codes for serine/threonine protein phosphatase type 1beta (PP1beta). Regulation of nonmuscle myosin activity is the single essential flw function that is nonredundant with the three closely related PP1alpha genes. Flw is thought to dephosphorylate the nonmuscle myosin regulatory light chain, Spaghetti Squash (Sqh); this inactivates the nonmuscle myosin heavy chain, Zipper (Zip). Thus,...

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Share to Drosophila Proteins
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Genes, Insect

Share to JNK Mitogen-Activated Protein Kinases

Share to Myosin Type II

Share to Phosphoprotein Phosphatases

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Source

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Identifiers

PMID: 17277363
DOI: 10.1534/genetics.106.067488
PMCID: PMC1855117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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