Article
Patterns of variation in DNA segments upstream of transcription start sites.
Human mutation - 1 May 2007
Labuda Damian, Labbé Catherine, Langlois Sylvie, Lefebvre Jean-Francois, Freytag Virginie, Moreau Claudia, Sawicki Jakub, Beaulieu Patrick, Pastinen Tomi, Hudson Thomas J, Sinnett Daniel
Abstract excerpt
It is likely that evolutionary differences among species are driven by sequence changes in regulatory regions. Likewise, polymorphisms in the promoter regions may be responsible for interindividual differences at the level of populations. We present an unbiased survey of genetic variation in 2-kb segments upstream of the transcription start sites of 28 protein-coding genes, characterized in five population groups...
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