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Article

Locating regions of differential variability in DNA and protein sequences.

Genetics - 1 Sept 1999

Tang H, Lewontin R C

Abstract excerpt

In the comparison of DNA and protein sequences between species or between paralogues or among individuals within a species or population, there is often some indication that different regions of the sequence are divergent or polymorphic to different degrees, indicating differential constraint or diversifying selection operating in different regions of the sequence. The problem is to test statistically whether the...

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Identifiers

PMID: 10471728
DOI: 10.1093/genetics/153.1.485
PMCID: PMC1460758

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