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Article

VCP/p97 AAA-ATPase does not interact with the endogenous wild-type cystic fibrosis transmembrane conductance regulator.

American journal of respiratory cell and molecular biology - 1 Jun 2007

Goldstein Rebecca F, Niraj Ashutosh, Sanderson Todd P, Wilson Landon S, Rab Andras, Kim Helen, Bebok Zsuzsa, Collawn James F

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel that is defective in cystic fibrosis. The most common mutation, DeltaF508 CFTR, is retained in the endoplasmic reticulum, retrotranslocated into the cytosol, and degraded by the proteasome. In a proteomics screen to identify DeltaF508 CFTR interacting proteins, we found that valosin-containing protein (VCP)/p97, a Type II AAA...

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Source

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Identifiers

PMID: 17272822
DOI: 10.1165/rcmb.2006-0365OC
PMCID: PMC1899338

Genes

CFTR
VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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VCP/p97 AAA-ATPase does not interact with the endogenous wild-type cystic fibrosis transmembrane conductance regulator.PMID 17272822Read ↗

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Derlin-1 promotes the efficient degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR folding mutants.Semantic proximity Read ↗

Defects in processing and trafficking of the cystic fibrosis transmembrane conductance regulator.Semantic proximity Read ↗

Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin.Semantic proximity Read ↗

Cystic fibrosis mutations lead to carboxyl-terminal fragments that highlight an early biogenesis step of the cystic fibrosis transmembrane conductance regulator.Semantic proximity Read ↗

N-Alpha-Acetyltransferases and Regulation of CFTR Expression.Semantic proximity Read ↗

Expression and degradation of the cystic fibrosis transmembrane conductance regulator in Saccharomyces cerevisiae.Semantic proximity Read ↗

p97 Is in a complex with cholera toxin and influences the transport of cholera toxin and related toxins to the cytoplasm.Semantic proximity Read ↗

CFTR and chaperones: processing and degradation.Semantic proximity Read ↗

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Non-conventional trafficking of the cystic fibrosis transmembrane conductance regulator through the early secretory pathway.Semantic proximity Read ↗

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