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Article

Interplay between ER exit code and domain conformation in CFTR misprocessing and rescue.

Molecular biology of the cell - 15 Feb 2010

Roy Gargi, Chalfin Elaine M, Saxena Anita, Wang Xiaodong

Abstract excerpt

Multiple mutations in cystic fibrosis transmembrane conductance regulator (CFTR) impair its exit from the endoplasmic reticulum (ER). We compared two processing mutants: DeltaF508 and the ER exit code mutant DAA. Although both have severe kinetic processing defect, DAA but not DeltaF508 has subst...

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Source

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Identifiers

PMID: 20032308
DOI: 10.1091/mbc.e09-05-0427
PMCID: PMC2820424

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20032308-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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