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Article

Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin.

Molecular and cellular biology - 1 Jun 2005

Farinha Carlos M, Amaral Margarida D

Abstract excerpt

Biosynthesis and folding of multidomain transmembrane proteins is a complex process. Structural fidelity is monitored by endoplasmic reticulum (ER) quality control involving the molecular chaperone calnexin. Retained misfolded proteins undergo ER-associated degradation (ERAD) through the ubiquitin-proteasome pathway. Our data show that the major degradation pathway of the cystic fibrosis transmembrane conductance...

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Source

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Identifiers

PMID: 15923638
DOI: 10.1128/MCB.25.12.5242-5252.2005
PMCID: PMC1140594

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin.PMID 15923638Read ↗

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