Article
High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2007
Nohara Atsushi, Kawashiri Masa-aki, Claudel Thierry, Mizuno Mihoko, Tsuchida Masayuki, Takata Mutsuko, Katsuda Shoji, Miwa Kenji, Inazu Akihiro, Kuipers Folkert, Kobayashi Junji, Koizumi Junji, Yamagishi Masakazu, Mabuchi Hiroshi
Abstract excerpt
OBJECTIVE: The genetic background of familial combined hyperlipidemia (FCHL) has not been fully clarified. Because several nuclear receptors play pivotal roles in lipid metabolism, we tested the hypothesis that genetic variants of nuclear receptors contribute to FCHL. METHODS AND RESULTS: We screened all the coding regions of the PPARalpha, PPARgamma2, PPARdelta, FXR, LXRalpha, and RXRgamma genes in 180...
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