Article
Genetic variants in adipose triglyceride lipase influence lipid levels in familial combined hyperlipidemia.
Atherosclerosis - 1 Nov 2010
Nanni Luisa, Quagliarini Fabiana, Megiorni Francesca, Montali Anna, Minicocci Ilenia, Campagna Filomena, Pizzuti Antonio, Arca Marcello
Abstract excerpt
OBJECTIVE: Familial combined hyperlipidemia (FCHL) has been associated with abnormalities in fatty acid metabolism. The adipose triglyceride lipase (PNPLA2) plays a pivotal role in the turnover of fatty acids in adipose tissue and liver. This study was designed to evaluate whether selected PNPLA2 variants may influence the susceptibility to FCHL or its lipid-related traits. METHODS: Four SNPs within the PNPLA2...
Topics
- Adult
- Cohort Studies
- Family Health
- Fatty Acids
- Female
- Genetic Predisposition to Disease
- Genetic Variation
- Haplotypes
- Humans
- Hyperlipidemia, Familial Combined
- Lipase
- Liver
- Male
- Middle Aged