Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variants in adipose triglyceride lipase influence lipid levels in familial combined hyperlipidemia.

Atherosclerosis - 1 Nov 2010

Nanni Luisa, Quagliarini Fabiana, Megiorni Francesca, Montali Anna, Minicocci Ilenia, Campagna Filomena, Pizzuti Antonio, Arca Marcello

Abstract excerpt

OBJECTIVE: Familial combined hyperlipidemia (FCHL) has been associated with abnormalities in fatty acid metabolism. The adipose triglyceride lipase (PNPLA2) plays a pivotal role in the turnover of fatty acids in adipose tissue and liver. This study was designed to evaluate whether selected PNPLA2 variants may influence the susceptibility to FCHL or its lipid-related traits. METHODS: Four SNPs within the PNPLA2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cohort Studies
Share to Family Health

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fatty Acids

Share to Haplotypes

Share to Hyperlipidemia, Familial Combined

Share to Lipase

Source

Identifiers

PMID: 20832801
DOI: 10.1016/j.atherosclerosis.2010.08.055

Genes

PNPLA2
MAF

Variants

rs7925131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variants in adipose triglyceride lipase influence lipid levels in familial combined hyperlipidemia.PMID 20832801Read ↗

Variants in the PPARgamma gene affect fatty acid and glycerol metabolism in familial combined hyperlipidemia.Semantic proximity Read ↗

Common variants in the lipoprotein lipase gene, but not those in the insulin receptor substrate-1, the beta3-adrenergic receptor, and the intestinal fatty acid binding protein-2 genes, influence the lipid phenotypic expression in familial combined hyperlipidemia.Semantic proximity Read ↗

Familial combined hyperlipidemia: An overview of the underlying molecular mechanisms and therapeutic strategiesSemantic proximity Read ↗

Genetics of familial combined hyperlipidemia.Semantic proximity Read ↗

The genetics of familial combined hyperlipidaemia.Semantic proximity Read ↗

Molecular mechanisms, prevalence, and molecular methods for familial combined hyperlipidemia disease: A reviewSemantic proximity Read ↗

Familial combined hyperlipidemia is a polygenic traitSemantic proximity Read ↗

Unraveling the complex genetics of familial combined hyperlipidemia.Semantic proximity Read ↗

The lipoprotein lipase gene in combined hyperlipidemia: evidence of a protective allele depletion.Semantic proximity Read ↗

Combined hyperlipidemia: familial but not (usually) monogenic.Semantic proximity Read ↗

Common genetic variants contribute to primary hypertriglyceridemia without differences between familial combined hyperlipidemia and isolated hypertriglyceridemia.Semantic proximity Read ↗

Genetic variants associated with triglyceride metabolism and fasting triglyceride concentrations: a systematic review and a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.