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Article

GP120: Target for Neutralizing HIV-1 Antibodies

16 Jan 2006

Abstract excerpt

The glycoprotein (gp) 120 subunit is an important part of the envelope spikes that decorate the surface of HIV-1 and a major target for neutralizing antibodies. However, immunization with recombinant gp120 does not elicit neutralizing antibodies against multiple HIV-1 isolates (broadly neutralizing antibodies), and gp120 failed to demonstrate vaccine efficacy in recent clinical trials. Ongoing crystallographic...

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Identifiers

PMID: 16551265
DOI: 10.1146/annurev.immunol.24.021605.090557

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