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Article

Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing.

The Journal of cell biology - 4 Feb 2002

Sacco-Bubulya Paula, Spector David L

Abstract excerpt

To examine the involvement of interchromatin granule clusters (IGCs) in transcription and pre-mRNA splicing in mammalian cell nuclei, the serine-arginine (SR) protein kinase cdc2-like kinase (Clk)/STY was used as a tool to manipulate IGC integrity in vivo. Both immunofluorescence and transmission electron microscopy analyses of cells overexpressing Clk/STY indicate that IGC components are completely redistributed...

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Identifiers

PMID: 11827980
DOI: 10.1083/jcb.200107017
PMCID: PMC2173333

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Source receipt: pubmed, retrieved 7 Sept 2026.

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