Tau binding to microtubules does not directly affect microtubule-based vesicle motility.

Abstract excerpt

Tau protein is a major microtubule (MT)-associated brain protein enriched in axons. Multiple functional roles are proposed for tau protein, including MT stabilization, generation of cell processes, and targeting of phosphotransferases to MTs. Recently, experiments involving exogenous tau expression in cultured cells suggested a role for tau as a regulator of kinesin-1-based motility. Tau was proposed to inhibit...

Topics

• Analysis of Variance
• Animals
• Axonal Transport
• Axons
• Cytoplasm
• Decapodiformes
• Humans
• Microscopy, Electron, Scanning
• Microtubule-Associated Proteins
• Microtubules
• Movement
• Mutation
• Optic Lobe, Nonmammalian
• Time Factors
• Transport Vesicles
• tau Proteins