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Article

Fission yeast Pib2 localizes to vacuolar membranes and regulates TOR complex 1 through evolutionarily conserved domains.

FEBS letters - 1 Dec 2024

Morozumi Yuichi, Hayashi Yumi, Chu Cuong Minh, Sofyantoro Fajar, Akikusa Yutaka, Fukuda Tomoyuki, Shiozaki Kazuhiro

Abstract excerpt

TOR complex 1 (TORC1) is a multi-protein kinase complex that coordinates cellular growth with environmental cues. Recent studies have identified Pib2 as a critical activator of TORC1 in budding yeast. Here, we show that loss of Pib2 causes severe growth defects in fission yeast cells, particularly when basal TORC1 activity is diminished by hypomorphic mutations in tor2, the gene encoding the catalytic subunit of...

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PMID: 39010328
DOI: 10.1002/1873-3468.14980

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