Article
Circulating levels of visfatin/pre-B-cell colony-enhancing factor 1 in relation to genotype, GFR, body composition, and survival in patients with CKD.
American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Feb 2007
Axelsson Jonas, Witasp Anna, Carrero Juan Jesús, Qureshi Abdul R, Suliman Mohamed E, Heimbürger Olof, Bárány Peter, Lindholm Bengt, Alvestrand Anders, Schalling Martin, Nordfors Louise, Stenvinkel Peter
Abstract excerpt
BACKGROUND: Visfatin, also known as pre-B-cell colony-enhancing factor 1 (PBEF-1), recently was shown to be secreted from adipocytes and have insulin-mimetic properties in mice. Because renal failure per se is associated with both increased levels of circulating peptides and marked insulin resistance, even in the absence of diabetes mellitus, we hypothesized that visfatin could be a factor linking inflammation,...
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