Radioimmunotherapy of human colon carcinomatosis xenograft with 90Y-ZCE025 monoclonal antibody: toxicity and tumor phenotype studies.

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Article

Radioimmunotherapy of human colon carcinomatosis xenograft with 90Y-ZCE025 monoclonal antibody: toxicity and tumor phenotype studies.

Cancer research - 1 Feb 1990

Esteban J M, Hyams D M, Beatty B G, Merchant B, Beatty J D

Abstract excerpt

Monoclonal antibody ZCE025 recognizes an epitope of the carcinoembryonic molecule (CEA). We have shown that when linked to 90Y, its localization in the tumor was sufficient to result in a significant tumoricidal effect in human colon carcinomatosis grown in the peritoneum of athymic mice. Intrape...

Topics

Animals
Antibodies, Monoclonal
Carcinoembryonic Antigen
Colonic Neoplasms
Female
Humans
Mice
Mice, Inbred BALB C
Neoplasm Transplantation
Neoplasms, Experimental
Phenotype
Transplantation, Heterologous
Yttrium Radioisotopes

Source

Open in PubMed

Identifiers

PMID: 2297752

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2297752-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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