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Article

Evaluation of a (64)Cu-labeled cystine-knot peptide based on agouti-related protein for PET of tumors expressing alphavbeta3 integrin.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Feb 2010

Jiang Lei, Kimura Richard H, Miao Zheng, Silverman Adam P, Ren Gang, Liu Hongguang, Li Peiyong, Gambhir Sanjiv Sam, Cochran Jennifer R, Cheng Zhen

Abstract excerpt

UNLABELLED: Recently, a truncated form of the agouti-related protein (AgRP), a 4-kDa cystine-knot peptide of human origin, was used as a scaffold to engineer mutants that bound to alpha(v)beta(3) integrin with high affinity and specificity. In this study, we evaluated the potential of engineered integrin-binding AgRP peptides for use as cancer imaging agents in living subjects. METHODS: Engineered AgRP peptides...

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Identifiers

PMID: 20124048
DOI: 10.2967/jnumed.109.069831
PMCID: PMC4143171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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