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Mediation of Apoptosis and Proliferation of Human Embryonic Stem Cells by Sphingosine-1-Phosphate

1 Dec 2006

Abstract excerpt

Human embryonic stem (hES) cells replicate by the process of self-renewal while maintaining their pluripotency. This process may be regulated by several different pathways and is poorly understood. In this study, sphingosine-1-phosphate (S1P) receptors were localized on hES cells of several cell lines (Shef 1-6), and their presence was verified by RT (reverse transcriptase)-PCR and western blotting. Dual staining...

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PMID: 17253942
DOI: 10.1089/scd.2006.15.789

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