Article
Interaction between 16S ribosomal RNA and ribosomal protein S12: differential effects of paromomycin and streptomycin.
Biochimie - 1 Dec 1991
O'Connor M, De Stasio E A, Dahlberg A E
Abstract excerpt
Strains containing a series of restrictive and non-restrictive mutations in ribosomal protein S12 have been transformed with plasmids carrying the rrnB operon with mutations at positions 1409 and 1491 in 16S rRNA. The effects of the double-mutant constructs have been measured by growth rate, paromomycin and streptomycin sensitivity, resistance and dependence. The results demonstrate a functional interaction...
Topics
- Bacterial Proteins
- Binding Sites
- Drug Resistance, Microbial
- Escherichia coli
- Genotype
- Mutation
- Paromomycin
- Phenotype
- Protein Biosynthesis
- RNA, Bacterial
- RNA, Ribosomal, 16S