Article
Genetic implication for an interaction between release factor one and ribosomal protein L7/L12 in vivo.
Journal of molecular biology - 7 Oct 1994
Zhang S, Rydén-Aulin M, Kirsebom L A, Isaksson L A
Abstract excerpt
Strains with mutant alleles of the genes encoding release factor one (RF1), prfA, and ribosomal protein L7/L12, rplL, have been analyzed. The prfA1 allele has previously been shown to be associated with temperature sensitivity for growth at 43 degrees C and increased misreading of the nonsense codons UAG and UAA. Here we show that the prfA1 mutation is a nucleotide substitution that results in an arginine to...
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