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Article

Various effects of paromomycin on tmRNA-directed trans-translation.

The Journal of biological chemistry - 25 Jul 2003

Takahashi Toshiharu, Konno Takayuki, Muto Akira, Himeno Hyouta

Abstract excerpt

trans-Translation is an unusual translation in which tmRNA plays a dual function as a tRNA and an mRNA to relieve the stalled translation on the ribosome. In this study, we examined the effects of an aminoglycoside antibiotic, paromomycin, on several tmRNA-related events in vitro. The results of a chemical footprinting study indicated that paromomycin molecules bind tmRNA at G332/G333 in the tRNA domain and A316...

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Identifiers

PMID: 12754221
DOI: 10.1074/jbc.M211724200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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