Article
Development of a new E. coli strain to detect oxidative mutation and its application to the fungicide o-phenylphenol and its metabolites.
Mutation research - 2 Apr 2007
Tani Shusuke, Yonezawa Yusuke, Morisawa Shinsuke, Nishioka Hajime
Abstract excerpt
Oxidative mutation is mainly induced by reactive oxygen species (ROS), such as the superoxide anion radical (O(2)(-)) and hydrogen peroxide (H(2)O(2)). However, in Escherichia coli (E. coli), ROS are eliminated by enzymes such as superoxide dismutase and catalase, which are coded by sodAB and katEG genes. In this study, to detect mutagens that induce oxidative mutation, a mutant (WP2katEGsodAB) with katEG and...
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